Spasms of the eyelid muscles Essential blepharospasm is a debilitating disorder
of progressive involuntary spasms of the eyelid muscles. Other muscles in
the face or neck may be involved as well. Terms that sometimes are used in
the description of this problem include dystonia (impaired or disordered
muscle tone) and dyskinesia (a defect in voluntary movement). The onset of
blepharospasm is typically in the fifth to sixth decade and is more common
in women than in men. Although the cause of essential blepharospasm is incompletely
understood, it is thought to be a result of "miscommunication" in the area(s)
of the brain responsible for control of the involved muscles.
The onset of essential blepharospasm usually is heralded by an increase in
blinking or squinting with progression toward repetitive forceful closure
and difficulty opening the eyelids. Blepharospasm is often made worse by
stress, fatigue, bright lights, watching television or driving, and social
interactions. Functional blindness in the presence of an otherwise normal
visual system may result. Sleep, relaxation, walking, talking and other "tricks" may
alleviate symptoms temporarily.
Systemic medications have limited efficacy in treating the disease. However,
some patients do benefit from such therapy alone or in conjunction with other
treatment modalities. Local injection of a medication called botulinum toxin
(brand name: Oculinum, Allergan Pharmaceuticals) last two to three months,
after which time the injections need to be repeated for continued relief.
As with any medication, "Oculinum" has side effects; fortunately, these typically
are mild and temporary.
Dry eyes, in particular, may be the cause of eyelid spasm or can aggravate
coexisting essential blepharospasm. Treatment of dry eye or other ocular
conditions may reduce eyelid spasm to a level that the patient can tolerate
without the need for additional medications or injections.
A related disorder, hemifacial spasm, involves involuntary spasms of muscles
on only one side of the face. This problem usually is caused by abnormal
stimulation of the facial nerve, which travels from the brain to the facial
muscles. Hemifacial spasm responds satisfactorily to botulinum toxin injections
in most patients.
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